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||"However, these numbers [obtained by labeling all mRNAs simultaneously, BNID 110665, 110666] were challenged by single molecule tracking [SMT] experiments that allowed following individual mRNAs in the nucleus and, at least in part, suggested a much slower mRNA diffusion rate. Using different labeling approaches (MS2 system, anti-sense oligos and molecular beacons), these SMT experiments estimated diffusion speeds varying from 0.005 µm^2/s
for a large dystrophin mRNA to 3.4 µm^2/s for a small beta-actin
mRNA [primary sources]."