| Range |
~8 %
|
| Organism |
Bacteria Escherichia coli |
| Reference |
Li GW, Burkhardt D, Gross C, Weissman JS. Quantifying absolute protein synthesis rates reveals principles underlying allocation of cellular resources. Cell. 2014 Apr 24 157(3):624-35. doi: 10.1016/j.cell.2014.02.033. p.632 left column 2nd paragraphPubMed ID24766808
|
| Method |
"In order to understand the amount of MetE expressed in the medium without
Met, [researchers] constructed a quantitative model to predict the optimal level of MetE
and growth rate. The model considers the cost and benefit of MetE synthesis
on growth rate. The cost function is based on previous observations that synthesis
of excess proteins competes with that of new ribosomal proteins, which
in turn leads to slower growth rate (Scott et al., 2010)." |
| Comments |
"MetE is a large and slow enzyme, whose production
consumes 8% of the total protein synthesis capacity in media
devoid of Met." At 27min doubling time |
| Entered by |
Uri M |
| ID |
110448 |