Estimated IL-4 gene opening rate in Th2 cells

Value 0.23 per hour
Organism Mouse Mus musculus
Reference Mariani, L., Schulz, E. G., Lexberg, M. H., Helmstetter, C., Radbruch, A., Löhning, M., & Höfer, T. (2010). Short-term memory in gene induction reveals the regulatory principle behind stochastic IL-4 expression. Molecular systems biology, 6(1). p.4 right column & p.7 right column 4th paragraphPubMed ID20393579
Method Abstract: "Here, [researchers] study the interleukin-4 gene (il4) in T-helper lymphocytes, combining mathematical modeling with the experimental quantification of expression variability and critical parameters."
Comments P.4 right column: "[Researchers] estimated a gene-opening rate of kG=0.23/h, implying that ~23% of the cells were activated in 1h of maximal TF-binding site occupancy."
Entered by mar.esther23
ID 110176