Overall ratio of male to female germ cell mutations
| Value | 3.5 unitless |
|---|---|
| Organism | Human Homo sapiens |
| Reference | Kasper CK, Buzin CH. Mosaics and haemophilia. Haemophilia. 2009 Nov15(6):1181-6. p. 1184, right column, 4th paragraph from topPubMed ID19473426 |
| Comments | The overall ratio of male to female mutations is about 3.5. Point mutations are fivefold to 10-fold higher in male germ cells vs. female ones. The male-to-female ratio at CpG dinucleotides is about six, as established by studies of haemophilia B [Sommer 1996 PMID 8875257]. Inversions are 10-fold higher in male germ cells vs. female ones, whereas deletions are more than fivefold higher in female germ cells [Becker 1996 PMID 8644728]. |
| Entered by | Uri M |
| ID | 105642 |