Permeability of the outer membrane to glucose

Range ~3 µm/sec
Organism Bacteria Escherichia coli
Reference Szenk M, Dill KA, de Graff AMR. Why Do Fast-Growing Bacteria Enter Overflow Metabolism? Testing the Membrane Real Estate Hypothesis. Cell Syst. 2017 Aug 235(2):95-104. doi: 10.1016/j.cels.2017.06.005. p.96 right column 2nd paragraphPubMed ID28755958
Primary Source Kojima S, Nikaido H. Permeation rates of penicillins indicate that Escherichia coli porins function principally as nonspecific channels. Proc Natl Acad Sci U S A. 2013 Jul 9110(28):E2629-34. doi: 10.1073/pnas.1310333110PubMed ID23798411
Comments P.96 right column 2nd paragraph: "[Investigators] compute the permeability of the E. coli outer membrane to glucose as roughly 3µm/s (Table S1A). While permeability could be increased by expanding the pore diameter, this has been observed to increase sensitivity to toxins, suggesting that porins also play a protective role for the cell (primary source)."
Entered by Uri M
ID 114683