A comparison of protein length distributions for Caenorhabditis elegans, Saccharomyces cerevisiae, E. coli and the archaebacterium Methanococcus jannaschi

Range Figure - link
Organism Various
Reference Netzer WJ, Hartl FU. Recombination of protein domains facilitated by co-translational folding in eukaryotes. Nature. 1997 Jul 24 388(6640):343-9. DOI: 10.1038/41024 p.343 figure 1PubMed ID9237751
Primary Source See refs in caption to figure
Comments P.343 left column: "Independent of the precise genetic mechanism involved, combining ancestral protein domains that were originally separate is apparently the basic principle by which many polypeptides with new functions evolved. This process has occurred with much higher frequency in eukaryotes than in prokaryotes, as is evident from a simple comparison of prokaryotic and eukaryotic protein structures using the information recently provided by several genome projects (Fig. 1). Although the size distribution of protein domains is uniform throughout the kingdoms of life (ref 2), eukaryotes contain a much greater number (and proportion) of longer polypeptides combining multiple domains."
Entered by Uri M
ID 113367