Fraction of ribosomes that are involved in translation under normal conditions

Range >90 %
Organism Microbes
Reference Bartholomäus A et al., Bacteria differently regulate mRNA abundance to specifically respond to various stresses. Philos Trans A Math Phys Eng Sci. 2016 Mar 13 374(2063). pii: 20150069. doi: 10.1098/rsta.2015.0069. p.7 4th paragraphPubMed ID26857681
Primary Source [52] Bremer H, Dennis P. Feedback control of ribosome function in Escherichia coli. Biochimie. 2008 Mar90(3):493-9. DOI: 10.1016/j.biochi.2007.10.008 [53] Warner JR, Vilardell J, Sohn JH . 2001 Economics of ribosome biosynthesis. Cold Spring Harb. Symp. Quant. Biol. 66, 567–574.PubMed ID17999920, 12762058
Method Abstract: "[Investigators] present a global analysis of the response of Escherichia coli to acute heat and osmotic stress. [They] combine deep sequencing of total mRNA and ribosome-protected fragments to provide a genome-wide map of the stress response at transcriptional and translational levels."
Comments P.7 4th paragraph: "Under normal conditions more than 90% of the ribosomes are involved in translation [primary Sources] thus leaving little capacity to reallocate ribosomes to new mRNAs [ref 54]." Primary sources [52] & [53] studied E. coli & yeast, respectively
Entered by Uri M
ID 112797