Morphology and cell migration kinetics of the proximal and the distal segments of the small intestinal epithelia

Range Table - link
Organism Pig Sus species
Reference Fan MZ, Stoll B, Jiang R, Burrin DG. Enterocyte digestive enzyme activity along the crypt-villus and longitudinal axes in the neonatal pig small intestine. J Anim Sci. 2001 Feb79(2):371-81. p.375 table 2PubMed ID11219446
Method Abstract:"Enterocyte migration rate was measured in the proximal and distal intestine using in vivo bromodeoxyuridine labeling."
Comments P.374 right column bottom paragraph to p.375 left column top paragraph:"As was determined from the Exp. 1, villus height was much greater (P<0.05) in the distal than in the proximal segment (Table 2). Crypt depth was greater (P<0.05) in the proximal than in the distal segment (Table 2). In order to examine whether differences in migration rates were responsible for the different villus heights in the proximal and the distal small intestinal segments of neonatal pigs, enterocyte migration rates along the crypt-villus axis were estimated with BrdU (Table 2). Regression analysis indicated a linear relationship (P<0.05) between distance of enterocyte migration and time of BrdU injection (Table 2). However, there were no differences (P=0.39) in the cell migration rate between the proximal and the distal segments (3.2±0.6 vs 3.0±0.7 µm/h, Table 2). The combination of greater villus height and similar migration rates suggests that the average life span of enterocytes in the distal small intestine is twice as long as in the proximal gut. Indeed, extrapolation of these linear regression equations gave an estimated mean enterocyte life span of 4.7±0.4 and 10.2±1.5 d for the proximal and the distal segments, respectively."
Entered by Uri M
ID 112183