Degradation rate of the homoserine lactone 3-Oxo-C6-AHL in vitro

Range ~0.0003 1/min
Organism bacteria
Reference Weber M, Buceta J. Noise regulation by quorum sensing in low mRNA copy number systems. BMC Syst Biol. 2011 Jan 20 5 :11. doi: 10.1186/1752-0509-5-11. p.7 left column top paragraphPubMed ID21251314
Primary Source [51] Kaufmann GF et al., Revisiting quorum sensing: Discovery of additional chemical and biological functions for 3-oxo-N-acylhomoserine lactones. Proc Natl Acad Sci U S A. 2005 Jan 11 102(2):309-14.PubMed ID15623555
Comments p.7 left column top paragraph:"Importantly, the dilution rate effectively modifies the degradation rate of the signaling molecule. In this regard, while some bacteria species have hydrolytic enzymes that degrade AHLs, generally speaking, bacteria that synthetize AHLs do not degrade them enzymatically. In fact, AHLs are chemically stable species in aqueous solutions [primary source]. The degradation rate of the homoserine lactone 3-Oxo-C6-AHL has been measured in vitro revealing that this autoinducer is rather stable: ~ 3·10^−4 min^−1 [primary source]. Measurements of the degradation rate of other AHL autoinducers show similar results." AHL=acyl homo- serine lactones
Entered by Uri M
ID 111994