Effect of codon order on variation of protein abundance in E. coli & S. cerevisiae

Range >20 %
Organism Microbes
Reference Reuveni S, Meilijson I, Kupiec M, Ruppin E, Tuller T. Genome-scale analysis of translation elongation with a ribosome flow model. PLoS Comput Biol. 2011 Sep7(9):e1002127. doi: 10.1371/journal.pcbi.1002127. p.2 left column top paragraphPubMed ID21909250
Method p.11 right column top paragraph:"[Investigators] described a novel analysis of large scale genomic data by a predictor/model that is based on the physical and dynamical nature of gene translation. Given the copy numbers of the tRNA genes in the host genome, [investigators'] model, the RFM [Ribosomal Flow Model], is based only on codon-bias. It can hence be applied when only the coding sequence of a gene is available and without additional data or information."
Comments p.2 left column top paragraph:"In addition, [investigators] provide the first direct estimate for the effect of codon order on protein abundance, showing that in E. coli and S. cerevisiae it can solely account for more than 20% of the variation in this quantity."
Entered by Uri M
ID 111574