| Range |
~70 %
|
| Organism |
Unspecified |
| Reference |
Tokuriki N, Stricher F, Serrano L, Tawfik DS. How protein stability and new functions trade off. PLoS Comput Biol. 2008 Feb 29 4(2):e1000002. doi: 10.1371/journal.pcbi.1000002. p.2 right column 5th paragraphPubMed ID18463696
|
| Method |
"[Researchers] performed a comprehensive analysis of
the type, location, and stability effects of mutations that
have conferred new enzymatic functions in laboratory
evolution experiments." |
| Comments |
"About 70% of the total residues in
enzymes occur in secondary structures such as alpha-helices and beta-sheets.
The remaining 30% are found in random coils. In contrast,
about 50% of active site residues are located in random coils [43]." |
| Entered by |
Uri M |
| ID |
109550 |