Cell cycle time of granules in adult rat dentate gyrus

Value 24.7 Hours
Organism Rat Rattus norvegicus
Reference Cameron HA, McKay RD. Adult neurogenesis produces a large pool of new granule cells in the dentate gyrus. J Comp Neurol. 2001 Jul 9 435(4):406-17. p.415 left column, bottom paragraphPubMed ID11406822
Method The total number of dividing cells in the region and their cell cycle time were estimated in young adult rats (9 weeks old, 300 g) by using double labeling with BrdU and [3H]thymidine to determine the length of their S-phase and cumulative BrdU labeling to identify the total number of dividing precursors as well as the proportion of cells in S-phase at a given time.
Comments Depends on developmental stage (see p.415 left column bottom paragraph)
Entered by Uri M
ID 106091