Median protein half-life

Range [Christiano et al., 2014] 8.8: [Martin-Perez and Villen, 2015] 2.0 hours
Organism Budding yeast Saccharomyces cerevisiae
Reference Ho B, Baryshnikova A, Brown GW. Unification of Protein Abundance Datasets Yields a Quantitative Saccharomyces cerevisiae Proteome. Cell Syst. 2018 Feb 28 6(2):192-205.e3. doi: 10.1016/j.cels.2017.12.004 p.202 left column 4th paragraphPubMed ID29361465
Primary Source Christiano R, Nagaraj N, Fröhlich F, Walther TC. Global proteome turnover analyses of the Yeasts S. cerevisiae and S. pombe. Cell Rep. 2014 Dec 11 9(5):1959-1965. doi: 10.1016/j.celrep.2014.10.065 AND Martin-Perez M, Villén J. Feasibility of protein turnover studies in prototroph Saccharomyces cerevisiae strains. Anal Chem. 2015 Apr 787(7):4008-14. doi: 10.1021/acs.analchem.5b00264PubMed ID25466257, 25767917
Comments P.202 left column 4th paragraph: "The apparent absence of a global protein response likely reflects the short half-life of a typical mRNA (~32 min) (BNID 115092) compared with the considerably longer median protein half-life (8.8 hr [primary source Christiano et al., 2014] 2.0 hr [primary source Martin-Perez and Villen, 2015])."
Entered by Uri M
ID 115093