Number of moles of tetrahydrofolate that can be converted into methylenetetrahydrofolate (Mlthf) using 1 mol of glucose, glycerol, or acetate

Range 1 mol glucose 4.55: 1 mol glycerol 2.48: 1 mol acetate 1.16 moles of tetrahydrofolate converted into Mlthf
Organism Bacteria Escherichia coli
Reference Kaleta C, Schäuble S, Rinas U, Schuster S. Metabolic costs of amino acid and protein production in Escherichia coli. Biotechnol J. 2013 Sep8(9):1105-14. doi: 10.1002/biot.201200267 p.1107 left column 2nd paragraphPubMed ID23744758
Method P.1107 left column 2nd paragraph: "Additionally, it was assumed that the carbon source is used to supply Mlthf in cases where the biosynthesis of the amino acid requires this compound."
Comments P.1107 left column 2nd paragraph: "Using linear programming, [investigators] determined that 1 mol of glucose can be used to convert 4.55 mol of tetrahydrofolate into Mlthf. For glycerol and acetate this number is 2.48 and 1.16, respectively."
Entered by Uri M
ID 114970