Estimated translation rate

Range 5 - 9 aa/sec
Organism Fungus Mucor racemosus
Reference Wang F, Durfee LA, Huibregtse JM. A cotranslational ubiquitination pathway for quality control of misfolded proteins. Mol Cell. 2013 May 9 50(3):368-78. doi: 10.1016/j.molcel.2013.03.009. p.373 left column bottom paragraphPubMed ID23583076
Primary Source M. Orlowski, J.F. Ross, Relationship of internal cyclic AMP levels, rates of protein synthesis and mucor dimorphism Arch. Microbiol., 129 (1981), pp. 353–356 AND J.F. Ross, M. Orlowski, Growth-rate-dependent adjustment of ribosome function in chemostat-grown cells of the fungus Mucor racemosus, J. Bacteriol., 149 (1982), pp. 650–653PubMed ID6269512, 6799491
Method 1st primary source abstract: "Changes in the intracellular pools of cyclic AMP and specific rates of protein synthesis have been described as correlates of the yeast-to-hypha conversion in Mucor racemosis. A further examination of the relationship between these physiological parameters and the cellular morphogenesis was conducted in the present study." 2nd primary source abstract: "The dimorphic fungus Mucor racemosus was grown as a yeast in a chemostat. Cellular growth rates were varied over a fourfold range under an atmosphere of N2 and over an eightfold range under CO2."
Comments P.373 left column bottom paragraph: "At an estimated translation rate of 5–9 amino acids/s (primary sources), 5 min of pactamycin treatment is sufficient to allow completion of translation of all but the longest proteins."
Entered by Uri M
ID 113359