Fraction of all cancers in which reactivated telomerase can be found

Range ~90 %
Organism Eukaryotes
Reference Hoeijmakers JH. DNA damage, aging, and cancer. N Engl J Med. 2009 Oct 8 361(15):1475-85. doi: 10.1056/NEJMra0804615. p.1482 right column top paragraphPubMed ID19812404
Primary Source [72] Shay JW, Keith WN. Targeting telomerase for cancer therapeutics. Br J Cancer 2008 98: 677-683 doi: 10.1038/sj.bjc.6604209PubMed ID18231105
Comments P.1482 left column bottom paragraph: "Not only does DNA damage initiate cancer, but cells may also induce DNA injury for protection against cancer. With every round of DNA replication, a number of protective telomeric repeats are lost at the ends of chromosomes because the telomerase enzyme that adds new repeats is silenced in most somatic cells [primary source]. Clonal outgrowth of a precancerous cell results in critically short telomeres that behave similarly to double-strand breaks, awakening the DNA damage-response system and triggering cell-cycle arrest and cell death. To grow, tumors must overcome this barrier, which explains why reactivated telomerase can be found in approximately 90% of all cancers [primary source]."
Entered by Uri M
ID 112973