| Range |
normal lymphocytes 7.67×10^−9±1.3×10^−9: colorectal epithelial cells 3.97×10^−8±2×10^−9 mutation/base/year
|
| Organism |
Human Homo sapiens |
| Reference |
Tomasetti C, Vogelstein B, Parmigiani G. Half or more of the somatic mutations in cancers of self-renewing tissues originate prior to tumor initiation. Proc Natl Acad Sci U S A. 2013 Feb 5 110(6):1999-2004. doi: 10.1073/pnas.1221068110. p.2001 left column top paragraphPubMed ID23345422
|
| Method |
"The expected value for the number XS(t) of passenger mutations
that originated in the precancer phase during tissue self-renewal
(Materials and Methods) is estimated to be
E[XS(t)]=S×u×t [1]
where E is the expectation operator, S is the total number of
DNA bases sequenced, u is the probability of a point mutation
per base per cell division, and t is the number of times the tissue has self-renewed before tumor initiation." |
| Comments |
"Using this formula [see Method section above], the
slopes derived from the data regressions, and letting S=3×10^7
(whole-exome sequencing), the number of somatic mutations
accumulated per base per year are estimated to be 7.67×10^-9±1.3×10^-9 (SE) in the normal lymphocytes that were precursors
to CLL [chronic lymphocytic leukemia], and 3.97×10^-8±2×10^-9 (SE) in colorectal epithelial
cells." |
| Entered by |
Uri M |
| ID |
111248 |