Number of somatic mutations accumulated per base per year

Range normal lymphocytes 7.67×10^−9±1.3×10^−9: colorectal epithelial cells 3.97×10^−8±2×10^−9 mutation/base/year
Organism Human Homo sapiens
Reference Tomasetti C, Vogelstein B, Parmigiani G. Half or more of the somatic mutations in cancers of self-renewing tissues originate prior to tumor initiation. Proc Natl Acad Sci U S A. 2013 Feb 5 110(6):1999-2004. doi: 10.1073/pnas.1221068110. p.2001 left column top paragraphPubMed ID23345422
Method "The expected value for the number XS(t) of passenger mutations that originated in the precancer phase during tissue self-renewal (Materials and Methods) is estimated to be E[XS(t)]=S×u×t [1] where E is the expectation operator, S is the total number of DNA bases sequenced, u is the probability of a point mutation per base per cell division, and t is the number of times the tissue has self-renewed before tumor initiation."
Comments "Using this formula [see Method section above], the slopes derived from the data regressions, and letting S=3×10^7 (whole-exome sequencing), the number of somatic mutations accumulated per base per year are estimated to be 7.67×10^-9±1.3×10^-9 (SE) in the normal lymphocytes that were precursors to CLL [chronic lymphocytic leukemia], and 3.97×10^-8±2×10^-9 (SE) in colorectal epithelial cells."
Entered by Uri M
ID 111248