Number of pre-ribosomes that cross each NPC (nuclear pore complex) per minute

Range ~25 pre-ribosomes/NPC/min
Organism Budding yeast Saccharomyces cerevisiae
Reference Oeffinger M, Zenklusen D. To the pore and through the pore: a story of mRNA export kinetics. Biochim Biophys Acta. 2012 Jun1819(6):494-506. doi: 10.1016/j.bbagrm.2012.02.011. p.501 left column 3rd paragraphPubMed ID22387213
Primary Source J. Warner, The economics of ribosome biosynthesis in yeast, Trends Biochem. Sci. 24 (1999) 437–440.PubMed ID10542411
Comments "Pre-ribosomal subunits, the second large complexes are a slightly higher burden for the NPC to transport: it has been estimated that ~25 pre-ribosomes cross each NPC per minute [primary source]."
Entered by Uri M
ID 110679