Cellular replacement rate of dopamine neuron

Value 20 new cells/day
Organism Mouse Mus musculus
Reference Lindvall O, McKay R. Brain repair by cell replacement and regeneration. Proc Natl Acad Sci U S A. 2003 Jun 24 100(13):7430-1 p.7431 middle column bottom paragraphPubMed ID12810949
Primary Source Zhao M et al., Evidence for neurogenesis in the adult mammalian substantia nigra. Proc Natl Acad Sci U S A. 2003 Jun 24 100(13):7925-30.PubMed ID12792021
Comments "Zhao et al. (primary source) provide the first experimental evidence that self-repair mechanisms may operate also in the adult substantia nigra. The results suggest that dopamine neurons are constantly turned over, they die and are replaced at a very low rate (20 new cells per day)."
Entered by Uri M
ID 109890