Glucose level in a fed anesthetized rat

Range Extracellular glucose in the brain ~2.5: Plasma 7.6 mM
Organism Rat Rattus norvegicus
Reference Routh VH. Glucose-sensing neurons: are they physiologically relevant? Physiol Behav. 2002 Jul76(3):403-13. p.404 right column 2nd paragraphPubMed ID12117577
Primary Source Silver IA, Erecinska M. Glucose-induced intracellular ion changes in sugar-sensitive hypothalamic neurons. J Neurophysiol. 1998 Apr79(4):1733-45. AND Silver IA, Erecinska M. Extracellular glucose concentration in mammalian brain: continuous monitoring of changes during increased neuronal activity and upon limitation in oxygen supply in normo-, hypo-, and hyperglycemic animals. J Neurosci. 1994 Aug14(8):5068-76PubMed ID9535943, 8046468
Method "Silver and Erecinska [primary sources] provided the only data in which extracellular brain glucose levels were simultaneously measured as plasma glucose levels were manipulated. In their studies, Silver and Erecinska clamped peripheral glucose and measured extracellular brain glucose using a glucose oxidase electrode."
Comments "Extracellular glucose in the brain was about 2.5 mM in a fed, anesthetized rat whose plasma glucose was 7.6 mM."
Entered by Uri M
ID 108954