The pore diameter of MscL in the open state

Range >~3 nm
Organism Bacteria Escherichia coli
Reference Haswell ES, Phillips R, Rees DC. Mechanosensitive channels: what can they do and how do they do it? Structure. 2011 Oct 12 19(10):1356-69. p.1358 right column bottom paragraphPubMed ID22000509
Primary Source Cruickshank CC, Minchin RF, Le Dain AC, Martinac B. Estimation of the pore size of the large-conductance mechanosensitive ion channel of Escherichia coli. Biophys J. 1997 Oct73(4):1925-31.PubMed ID9336188
Method Sieving experiments
Comments MscL=Mechanosensitive channel of Large conductance. The pore diameter of MscL in the open state, for example, has been estimated from sieving experiments to exceed ~3 nm (primary source), accommodating the passages of small proteins up to 9 kD (van den Bogaart et al., 2007).
Entered by Uri M
ID 107628