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Percent of midline glia that are eliminated through apoptosis during embryogenesis

Range	~75 %
Organism	Fruit fly Drosophila melanogaster
Reference	Hidalgo A, Kato K, Sutcliffe B, McIlroy G, Bishop S, Alahmed S. Trophic neuron-glia interactions and cell number adjustments in the fruit fly. Glia. 2011 Sep59(9):1296-303. doi:10.1002/glia.21092 p.1300 left column bottom paragraphPubMed ID21732425
Primary Source	Sonnenfeld MJ, Jacobs JR. Apoptosis of the midline glia during Drosophila embryogenesis: a correlation with axon contact. Development. 1995 Feb121(2):569-78. AND Zhou L, Schnitzler A, Agapite J, Schwartz LM, Steller H, Nambu JR. Cooperative functions of the reaper and head involution defective genes in the programmed cell death of Drosophila central nervous system midline cells. Proc Natl Acad Sci U S A. 1997 May 13 94(10):5131-6. AND Zhou L, Hashimi H, Schwartz LM, Nambu JR. Programmed cell death in the Drosophila central nervous system midline. Curr Biol. 1995 Jul 1 5(7):784-90. AND Noordermeer JN, Kopczynski CC, Fetter RD, Bland KS, Chen WY, Goodman CS. Wrapper, a novel member of the Ig superfamily, is expressed by midline glia and is required for them to ensheath commissural axons in Drosophila. Neuron. 1998 Nov21(5):991-1001. AND Jacobs JR. The midline glia of Drosophila: a molecular genetic model for the developmental functions of glia. Prog Neurobiol. 2000 Dec62(5):475-508.PubMed ID7768193, 9144202, 7583125, 9856456, 10869780
Comments	In flies, the midline glia are produced in excess and ~75% of them are eliminated through apoptosis during embryogenesis (primary sources).
Entered by	Uri M
ID	107586