Fraction of >50,000 conopeptides (neuroactive peptides of the venom) that have been characterized pharmacologically

Range <0.1 %
Organism Predatory cone snail Conus spp.
Reference Singer HM et al., Selective purification of recombinant neuroactive peptides using the flagellar type III secretion system. MBio. 2012 May 29 3(3). pii: e00115-12. doi: 10.1128/mBio.00115-12 p.5 right columnPubMed ID22647788
Primary Source [22] Terlau H, Olivera BM. Conus venoms: a rich source of novel ion channel-targeted peptides Physiol Rev. 2004 Jan84(1):41-68 DOI: 10.1152/physrev.00020.2003 [28] Lewis RJ, Garcia ML. Therapeutic potential of venom peptides. Nat Rev Drug Discov. 2003 Oct2(10):790-802. DOI: 10.1038/nrd1197PubMed ID14715910, 14526382
Comments P.5 left column bottom paragraph: "More than 500 species of fish-, mollusk-, and worm-hunting cone snails have evolved, and every Conus species appears to have a repertoire of around 100 different venom components, mostly small, disulfide-rich peptides that rapidly affect the prey organism at multiple targets. Each neuroactive peptide of the venom is highly specific for an individual channel isoform, and it is estimated that >50,000 conopeptides exist, but less than 0.1% have been characterized pharmacologically (primary sources)."
Entered by Uri M
ID 115226