Protein synthesis rate

Range 10 - 20 aa/sec
Organism Bacteria Escherichia coli
Reference Kudva R, Denks K, Kuhn P, Vogt A, Müller M, Koch HG. Protein translocation across the inner membrane of Gram-negative bacteria: the Sec and Tat dependent protein transport pathways. Res Microbiol. 2013 Jul-Aug164(6):505-34. doi: 10.1016/j.resmic.2013.03.016 p.511 right column bottom paragraphPubMed ID23567322
Primary Source Talkad V, Schneider E, Kennell D. Evidence for variable rates of ribosome movement in Escherichia coli. J Mol Biol. 1976 Jun 14 104(1):299-303.PubMed ID785012
Comments P.511 right column bottom paragraph: "Proteins are synthesised at a rate of 10-20 amino acids per second (primary source), the ribosomal tunnel has a length of approx. 100 Å (Nissen et al., 2000) and a single amino acid occupies approx. 3.5 Å. Thus, within a few seconds after translation is initiated, the polypeptide, given that it is in extended conformation, starts to emerge from the ribosomal exit tunnel."
Entered by Uri M
ID 113762