Kinetic parameters for amino-acid related compounds

Range Table - link µM
Organism African clawed frog Xenopus laevis
Reference Uchino H et al., Transport of amino acid-related compounds mediated by L-type amino acid transporter 1 (LAT1): insights into the mechanisms of substrate recognition. Mol Pharmacol. 2002 Apr61(4):729-37. p.732 table 1PubMed ID11901210
Method "To understand the mechanisms of substrate recognition, [researchers] have examined the LAT1-mediated transport using a Xenopus laevis oocyte expression system."
Comments "...amino acids with bulky side chains are competitive inhibitors of LAT1-mediated transport with Ki values comparable with those of L-dopa and other phenylalanine derivatives (Table 1)."
Entered by Uri M
ID 109027