Mean residence time of endogenously secreted insulin

Value 71 minutes
Organism Unspecified
Reference Duckworth WC, Bennett RG, Hamel FG. Insulin degradation: progress and potential. Endocr Rev. 1998 Oct19(5):608-24.PubMed ID9793760
Primary Source Hovorka R, Powrie JK, Smith GD, Sonksen PH, Carson ER, Jones RH 1993 Five-compartment model of insulin kinetics and its use to investigate action of chloroquine in NIDDM. Am J Physiol 265:E162–E175
Method Estimation using a five-compartment model
Comments with 62 min spent bound to the liver receptor, 6 min bound to peripheral receptors, and 3 min in blood or interstitial fluid
Entered by Uri M
ID 103355