Ratio between amount of damage due to reactive oxygen species between mitochondrial DNA and nuclear DNA

Value 10 Unitless
Organism Unspecified
Reference Turunen M, Olsson J, Dallner G. Metabolism and function of coenzyme Q. Biochim Biophys Acta. 2004 Jan 281660(1-2):171-99.PubMed ID14757233
Primary Source Ozawa T. Genetic and functional changes in mitochondria associated with aging. Physiol Rev. 1997 Apr77(2):425-64.PubMed ID9114820
Comments Due to the relatively high production of ROS in mitochondria, lack of protective histones and limited ability of repair, mitochondrial DNA has about 10-fold higher oxidative damage than nuclear DNA
Entered by Uri M
ID 103277