Length of cycle in which expression of Neurog2 oscillates in dividing cortical progenitors

Range 2-3 hours
Organism Fruit fly Drosophila melanogaster
Reference Huang C, Chan JA, Schuurmans C. Proneural bHLH genes in development and disease. Curr Top Dev Biol. 2014 110: 75-127. doi: 10.1016/B978-0-12-405943-6.00002-6 p.86 bottom paragraphPubMed ID25248474
Primary Source Shimojo H, Ohtsuka T, Kageyama R. Oscillations in notch signaling regulate maintenance of neural progenitors. Neuron. 2008 Apr 10 58(1):52-64. doi: 10.1016/j.neuron.2008.02.014PubMed ID18400163
Method Primary source abstract: "Here, by using a real-time imaging method, [investigators] found that Hes1 expression dynamically oscillates in neural progenitors."
Comments P.86 bottom paragraph: "Several mechanisms underlie such temporal control of Neurog2 activity. First, Neurog2 is not stably expressed in dividing cortical progenitors, but rather oscillates in 2–3 h cycles (primary source, Fig. 2.3)."
Entered by Uri M
ID 117242