Average lifetime of basal filopodia

Range ~500 sec
Organism Fruit fly Drosophila melanogaster
Reference Axelrod JD. Delivering the lateral inhibition punchline: it's all about the timing. Sci Signal. 2010 Oct 26 3(145):pe38. doi: 10.1126/scisignal.3145pe38 p.2 right column bottom paragraphPubMed ID20978236
Primary Source [22] Cohen M, Georgiou M, Stevenson NL, Miodownik M, Baum B. Dynamic filopodia transmit intermittent Delta-Notch signaling to drive pattern refinement during lateral inhibition. Dev Cell. 2010 Jul 20 19(1):78-89. doi: 10.1016/j.devcel.2010.06.006PubMed ID20643352
Method Live imaging
Comments P.2 right column bottom paragraph: "Because basal filopodia extending up to several cell diameters beyond the nearest neighbors are required to generate low-density spacing (ref 21), Cohen and co-workers examined basal filopodia using their live imaging protocol. Remarkably, they observed that basal filopodia are extremely dynamic, with an average lifetime of around 500 s."
Entered by Uri M
ID 117241