Period of maturation (see Comments section) of INPs [intermediate progenitors (of type II neuroblasts)]

Range 4 - 6 hours
Organism Fruit fly Drosophila melanogaster
Reference Homem CC, Knoblich JA. Drosophila neuroblasts: a model for stem cell biology. Development. 2012 Dec 1 139(23):4297-310. doi: 10.1242/dev.080515 p.4301 left column bottom paragraphPubMed ID23132240
Primary Source Bayraktar OA, Boone JQ, Drummond ML, Doe CQ. Drosophila type II neuroblast lineages keep Prospero levels low to generate large clones that contribute to the adult brain central complex. Neural Dev. 2010 Oct 1 5: 26. doi: 10.1186/1749-8104-5-26PubMed ID20920301
Method Primary source Bayraktar et al. abstract: "[Investigators] misexpress prospero using the 19H09-Gal4 line (expressed in type II neuroblasts but no adjacent type I neuroblasts) or 9D11-Gal4 line (expressed in INPs [intermediate progenitors] but not type II neuroblasts)... In addition, [they] use 9D11 lineage tracing to show that type II lineages generate both small-field and large-field neurons within the adult central complex, a brain region required for locomotion, flight, and visual pattern memory."
Comments P.4298 left column bottom paragraph: "Immature INPs do not divide but pass through a 4- to 6-hour period of maturation, after which they start re-expressing NB markers and are then called mature INPs (primary source)."
Entered by Uri M
ID 117238