| Range |
~5000 type II NBs (neuroblasts)
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| Organism |
Fruit fly Drosophila melanogaster |
| Reference |
Homem CC, Knoblich JA. Drosophila neuroblasts: a model for stem cell biology. Development. 2012 Dec 1 139(23):4297-310. doi: 10.1242/dev.080515 p.4298 left column top paragraphPubMed ID23132240
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| Primary Source |
Izergina N, Balmer J, Bello B, Reichert H. Postembryonic development of transit amplifying neuroblast lineages in the Drosophila brain. Neural Dev. 2009 Dec 11 4: 44. doi: 10.1186/1749-8104-4-44 AND Bayraktar OA, Boone JQ, Drummond ML, Doe CQ. Drosophila type II neuroblast lineages keep Prospero levels low to generate large clones that contribute to the adult brain central complex. Neural Dev. 2010 Oct 1 5: 26. doi: 10.1186/1749-8104-5-26PubMed ID20003348, 20920301
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| Method |
Primary source Izergina et al. abstract: "In this report [investigators] use MARCM [Mosaic analysis with a repressible cell marker]-based clonal analysis together with immunocytochemical labeling techniques to investigate the type and fate of neural cells generated in the DM [dorsomedial neuroblast] lineages." Primary source Bayraktar et al. abstract: "[Investigators] misexpress prospero using the 19H09-Gal4 line (expressed in type II neuroblasts but no adjacent type I neuroblasts) or 9D11-Gal4 line (expressed in INPs [intermediate progenitors] but not type II neuroblasts)... In addition, [they] use 9D11 lineage tracing to show that type II lineages generate both small-field and large-field neurons within the adult central complex, a brain region required for locomotion, flight, and visual pattern memory." |
| Comments |
P.4298 left column top paragraph: "Together, type II NBs contribute ~5000 adult neural cells that form major neuropile substructures of the brain, such as the central complex (primary sources)." Primary source Izergina et al. abstract: "Together, these DM [dorsomedial] neuroblast lineages comprise over 5,000 adult-specific neural cells and thus represent a substantial part of the brain." |
| Entered by |
Uri M |
| ID |
117237 |