Fraction of granule cell neurons that are generated each month in the dentate gyrus

Range ~6 % of the total granule cell population
Organism Rat Rattus norvegicus
Reference Hanson ND, Owens MJ, Nemeroff CB. Depression, antidepressants, and neurogenesis: a critical reappraisal. Neuropsychopharmacology. 2011 Dec36(13):2589-602. doi: 10.1038/npp.2011.220 p.2591 left column bottom paragraphPubMed ID21937982
Primary Source Cameron HA, McKay RD. Adult neurogenesis produces a large pool of new granule cells in the dentate gyrus. J Comp Neurol. 2001 Jul 9 435(4):406-17PubMed ID11406822
Method Primary source abstract: "The S-phase marker bromodeoxyuridine (BrdU) has been extensively used in recent studies of adult neurogenesis, but it has been carefully tested only in the embryonic brain. Here, [investigators] show that a high dose of BrdU (300 mg/kg) is a specific, quantitative, and nontoxic marker of dividing cells in the adult rat dentate gyrus, whereas lower doses label only a fraction of the S-phase cells. By using this high dose of BrdU along with a second S-phase marker, [(3)H]thymidine, [they] found..."
Comments P.2591 left column bottom paragraph: "The number of granule cell neurons generated each month in the dentate gyrus is approximately 6% of the total population (primary source). The magnitude of this continuous production of new neurons indicates that they play an important role in hippocampal function, for which several possible hypotheses have been proposed." Primary source abstract: "This number of new granule neurons generated each month is 6% of the total size of the granule cell population and 30-60% of the size of the afferent and efferent populations (West et al. [1991] Anat Rec 231:482-497, Mulders et al. [1997] J Comp Neurol 385:83-94)."
Entered by Uri M
ID 117234