Fraction of neurons that are added to DG (dentate gyrus, in the hippocampus) after birth

Range ~40 %
Organism macaque
Reference Josselyn SA, Frankland PW. Infantile amnesia: a neurogenic hypothesis. Learn Mem. 2012 Aug 16 19(9):423-33. doi: 10.1101/lm.021311.110 p.427 left column 2nd paragraphPubMed ID22904373
Primary Source Jabès A, Lavenex PB, Amaral DG, Lavenex P. Quantitative analysis of postnatal neurogenesis and neuron number in the macaque monkey dentate gyrus. Eur J Neurosci. 2010 Jan31(2):273-85. doi: 10.1111/j.1460-9568.2009.07061.xPubMed ID20074220
Method Primary source abstract: "[Investigators] performed design-based, stereological studies of neuron number and size, and volume of the dentate gyrus layers in rhesus macaque monkeys (Macaca mulatta) of different postnatal ages."
Comments P.427 left column 2nd paragraph: "Given the differences in lifespan between monkeys and rats (the lifespan of a monkey is ∼20–30 yr compared to 2–3 yr for rats), the overall contribution of postnatal neurogenesis in these two species is remarkably similar. Indeed, Jabès and colleagues estimate that ∼40% of neurons are added to the monkey DG after birth. Together, these data suggest that postnatal neurogenesis could have a substantial impact on hippocampal circuit function in rodents and primates, including humans." Primary source abstract: "[Investigators] found that about 40% of the total number of granule cells observed in mature 5-10-year-old macaque monkeys are added to the granule cell layer postnatally: 25% of these neurons are added within the first three postnatal months."
Entered by Uri M
ID 117227