Worldwide rates of cognitive impairment in preterm infants (gw=gestational weeks)

Range 24 gw 14–39%: 25 gw 10-30%: 26 gw 4-24%: 29 gw 11-18% % of infants with cognitive impairment
Organism Human Homo sapiens
Reference Malik S et al., Neurogenesis continues in the third trimester of pregnancy and is suppressed by premature birth. J Neurosci. 2013 Jan 9 33(2):411-23. doi: 10.1523/JNEUROSCI.4445-12.2013 p.421 right column 2nd paragraphPubMed ID23303921
Primary Source Emsley HC et al., Increased survival and deteriorating developmental outcome in 23 to 25 week old gestation infants, 1990-4 compared with 1984-9. Arch Dis Child Fetal Neonatal Ed. 1998 Mar78(2):F99-104 DOI: 10.1136/fn.78.2.f99 AND Stephens BE, Vohr BR. Neurodevelopmental outcome of the premature infant. Pediatr Clin North Am. 2009 Jun56(3):631-46, Table of Contents. doi: 10.1016/j.pcl.2009.03.005PubMed ID9577278, 19501696
Method Primary source Emsley et al. abstract: "Obstetric and neonatal variables having the strongest association with both survival to discharge from a regional neonatal medical unit and neurodevelopmental disability in 192 infants of 23 to 25 weeks of gestation, born in 1984 to 1994, were studied as a group and in two cohorts (1984 to 1989 n = 96 and 1990 to 1994 n = 96). The data collected included CRIB (clinical risk index for babies) scores and cranial ultrasound scan findings. The children were followed up at outpatient clinics."
Comments P.421 right column 2nd paragraph: "Worldwide rates of cognitive impairment in preterm infants increase with a decrease in gestational age (14–39% for 24 gw, 10–30% for 25 gw, 4–24% for 26 gw, and 11–18% for 29 gw) (primary sources). This inverse relationship between gestational age and the incidence of cognitive disability, inattention, hyperactivity, and abnormal motor outcomes in premature infants suggests that neurogenesis is suppressed in these infants secondary to preterm birth and perinatal insults (Vohr and Msall, 1997)."
Entered by Uri M
ID 117219