Fraction of medium spiny neurons that express both [dopamine] D1 and [dopamine] D2 receptor mRNA

Value 40 %
Organism Rat Rattus norvegicus
Reference Nishi A, Kuroiwa M, Shuto T. Mechanisms for the modulation of dopamine d(1) receptor signaling in striatal neurons. Front Neuroanat. 2011 Jul 18 5: 43. doi: 10.3389/fnana.2011.00043 p.4 left column bottom paragraphPubMed ID21811441
Primary Source Surmeier DJ, Song WJ, Yan Z. Coordinated expression of dopamine receptors in neostriatal medium spiny neurons. J Neurosci. 1996 Oct 15 16(20):6579-91PubMed ID8815934
Method Primary source abstract: "To test this hypothesis, [investigators] examined the expression of DA [dopamine] receptors in individual neostriatal neurons by patch-clamp and RT-PCR techniques."
Comments P.4 left column bottom paragraph: "Gene expression analysis using single cell RT-PCR technique estimated that 40% of medium spiny neurons express both D1 and D2 receptor mRNA (primary source)."
Entered by Uri M
ID 117205