| Value |
200
µm
|
| Organism |
Rat Rattus norvegicus |
| Reference |
Connors BW, Long MA. Electrical synapses in the mammalian brain. Annu Rev Neurosci. 2004 27: 393-418 DOI: 10.1146/annurev.neuro.26.041002.131128 p.402 2nd paragraphPubMed ID15217338
|
| Primary Source |
Amitai Y et al., The spatial dimensions of electrically coupled networks of interneurons in the neocortex. J Neurosci. 2002 May 15 22(10):4142-52 DOI: 20026371PubMed ID12019332
|
| Method |
Primary source abstract: "[Investigators] studied the spatial organization of two types of interneurons in the rat somatosensory cortex: fast-spiking (FS) parvalbumin-immunoreactive (PV+) cells, and low threshold-spiking (LTS) somatostatin-immunoreactive (SS+) cells... The dendritic arbors of FS and LTS cells were reconstructed from electrophysiologically characterized, biocytin-filled cells: the two cell types had only minor differences in the number and span of their dendrites." |
| Comments |
P.402 2nd paragraph: "Electrically coupled networks of interneurons are large. The probability and strength of coupling falls with intersomatic distance, and beyond 200 μm no coupling has been detected between pairs of either FS or LTS cells (primary source). Considering this spatial profile of coupling along with measures of the density of interneurons, one infers that each interneuron is coupled to between 20 and 40 neighboring interneurons. It is not known whether such interneuron syncytia extend indefinitely across the cortical mantle, or whether they have distinct boundaries." Primary source abstract: "Paired recordings in layer 4 demonstrated that both the probability of coupling and the coupling coefficient drop steeply with intersomatic distance, reaching zero beyond 200 microm." |
| Entered by |
Uri M |
| ID |
117163 |