| Range |
in peripheral capillaries 2-20: in brain endothelium >1000 Ω.cm^2
|
| Organism |
Rat Rattus norvegicus |
| Reference |
Abbott NJ, Rönnbäck L, Hansson E. Astrocyte-endothelial interactions at the blood-brain barrier. Nat Rev Neurosci. 2006 Jan7(1):41-53 DOI: 10.1038/nrn1824 p.42 right column bottom paragraphPubMed ID16371949
|
| Primary Source |
[21] Butt AM, Jones HC, Abbott NJ. Electrical resistance across the blood-brain barrier in anaesthetized rats: a developmental study. J Physiol. 1990 Oct429: 47-62 DOI: 10.1113/jphysiol.1990.sp018243PubMed ID2277354
|
| Method |
Primary source abstract: "Ion permeability of the blood-brain barrier was studied by in situ measurement of transendothelial electrical resistance in anaesthetized rats aged between 17 days gestation and 33 days after birth, and by electron microscopic examination of lanthanum permeability in fetal and neonatal rats aged up to 10 days old." |
| Comments |
P.42 right column bottom paragraph: "The tight junctions are more complex in the brain endothelium, seen in freeze–fracture images as a network of strands formed by intramembranous particles, and occlude the intercellular cleft more effectively (refs 11, 20). These junctions significantly restrict even the movement of small ions such as Na+ and Cl−, so that the transendothelial electrical resistance (TEER), which is typically 2–20 ohm.cm^2 in peripheral capillaries, can be >1,000 ohm.cm^2 in brain endothelium (primary source)." |
| Entered by |
Uri M |
| ID |
117113 |