Predominance of Meningiomas (primary extra-axial tumors of the central nervous system (CNS)) in females

Range ~3:1 females:males
Organism Human Homo sapiens
Reference Polyzoidis S, Koletsa T, Panagiotidou S, Ashkan K, Theoharides TC. Mast cells in meningiomas and brain inflammation. J Neuroinflammation. 2015 Sep 17 12 :170. doi: 10.1186/s12974-015-0388-3 p.1 left column top paragraphPubMed ID26377554
Primary Source [2] Carroll RS, Zhang J, Black PM. Expression of estrogen receptors alpha and beta in human meningiomas. J Neurooncol. 1999 Apr42(2):109-16 [3] Maxwell M, Galanopoulos T, Neville-Golden J, Antoniades HN. Expression of androgen and progesterone receptors in primary human meningiomas. J Neurosurg. 1993 Mar78(3):456-62 DOI: 10.3171/jns.1993.78.3.0456 [4] Probst-Cousin S et al., Secretory meningioma: clinical, histologic, and immunohistochemical findings in 31 cases. Cancer. 1997 May 15 79(10):2003-15 DOI: 10.1002/(sici)1097-0142(19970515)79:10<2003::aid-cncr23>3.0.co2-xPubMed ID10421067, 8433149, 9149029
Method Primary source [4] abstract: "In the tumor collection used in this study, secretory meningiomas represented 3% of meningiomas. The female-to-male ratio was 9:1."
Comments P.1 left column top paragraph: "Meningiomas are primary extra-axial tumors of the central nervous system (CNS) with an incidence of ~2 in 100,000 in adults [BNID 117049]. There is an approximate 3:1 female predominance of these tumors mainly attributed to the action of oestrogens [primary sources]." Primary source [2] abstract: "The predominance of meningiomas in females, their accelerated growth during the luteal phase of the menstrual cycle and during pregnancy: and the association between meningiomas and breast cancer has led to a number of studies examining the potential role of steroids on the growth of meningiomas." Primary source [3] abstract: "Meningiomas are common brain tumors that show a predilection for females and become more aggressive during pregnancy and menses. The existence of gender-specific hormone receptors in meningiomas has long been a matter of controversy, the recent cloning of androgen, estrogen, and progesterone receptors has facilitated their direct evaluation."
Entered by Uri M
ID 117050