Number of validated hormone-responsive androgen receptor target genes in immortalized human prostate epithelial cell line

Value 172 target genes
Organism Human Homo sapiens
Reference Carroll SB. Evo-devo and an expanding evolutionary synthesis: a genetic theory of morphological evolution. Cell. 2008 Jul 11 134(1):25-36. doi: 10.1016/j.cell.2008.06.030 p.30 right column top paragraphPubMed ID18614008
Primary Source Bolton EC et al., Cell- and gene-specific regulation of primary target genes by the androgen receptor. Genes Dev. 2007 Aug 15 21(16):2005-17 DOI: 10.1101/gad.1564207PubMed ID17699749
Method Primary source abstract: "[Investigators] used expression profiling of an immortalized human prostate epithelial cell line to identify 205 androgen-responsive genes (ARGs), most of them novel. In addition, [they] performed chromatin immunoprecipitation to identify 524 AR [androgen receptor] binding regions and validated in reporter assays the ARE [androgen response element] activities of several such regions."
Comments P.30 right column top paragraph: "For example, Stark et al. (BNID 117005) estimated that there are, on average, 124 target genes for each of the 67 Drosophila transcription factors they analyzed. This figure is exceeded by the number of validated hormone-responsive androgen receptor target genes in just one human cell type (172: primary source) and the number of signal-regulated STAT3 targets in another cell type (∼300 BNID 117007)."
Entered by Uri M
ID 117006