Fraction of protein sequences that consist of more than one domain

Range ~67 %
Organism Bacteria Mycoplasma genitalium
Reference Apic G, Gough J, Teichmann SA. Domain combinations in archaeal, eubacterial and eukaryotic proteomes. J Mol Biol. 2001 Jul 6 310(2):311-25 DOI: 10.1006/jmbi.2001.4776 p.312 left column bottom paragraphPubMed ID11428892
Primary Source [8] S.A Teichmann, J Park, C Chothia Structural assignments to the Mycoplasma genitalium proteins show extensive gene duplications and domain rearrangements Proc. Natl Acad. Sci. USA, 95 (1998), pp. 14658-14663 DOI: 10.1073/pnas.95.25.14658PubMed ID9843945
Method Primary source abstract: "The parasitic bacterium Mycoplasma genitalium has a small, reduced genome with close to a basic set of genes. As a first step toward determining the families of protein domains that form the products of these genes, [investigators] have used the multiple sequence programs PSI-BLAST and GEANFAMMER to match the sequences of the 467 gene products of M. genitalium to the sequences of the domains that form proteins of known structure [Protein Data Bank (PDB) sequences]."
Comments P.312 left column bottom paragraph: "Previously, Teichmann et al. (primary source) observed that about two-thirds of the sequences of the bacterium Mycoplasma genitalium consist of more than one domain."
Entered by Uri M
ID 116986