Number of amino acids protruding from the ribosome when N-terminal acetylation (N-Ac) occurs

Range 25 - 50 amino acids
Organism Eukaryotes
Reference Van Damme P et al., NatF contributes to an evolutionary shift in protein N-terminal acetylation and is important for normal chromosome segregation. PLoS Genet. 2011 Jul7(7):e1002169. doi: 10.1371/journal.pgen.1002169 p.1 left columnPubMed ID21750686
Primary Source Table - link
Comments P.1 left column: "N-terminal acetylation (N-Ac) is a common modification of proteins, but its general role has remained rather enigmatic. For specific proteins, N-Ac is recognized as an important regulator of function and localization [refs 1–4]. Recently, it was suggested that it may act as a general destabilization signal for some yeast proteins, [primary source 5] while other reports imply that it might serve as a stabilizer, for instance by blocking N-terminal ubiquitination mediated degradation [primary source 6]. N-Ac in eukaryotes mainly occurs co-translationally when 25–50 amino acids protrude from the ribosome, by the action of ribosome associated N-terminal acetyltransferases (NATs) [primary sources]."
Entered by Uri M
ID 116983