Comments |
P.112 3rd paragraph: “The conserved portions of minimal sets for different lifestyles are easy to identify using the tools for phyletic pattern analysis that are associated with the COG [Clusters of Orthologous Groups of proteins] system (Table 5). The challenge lies in delineating the NOD [nonorthologous gene displacement] cases to supplement these conserved sets of proteins, which requires careful computational analyses and biological reasoning and is beyond the scope of this review, but even examination of the conserved portions is of some interest. It shows, for example, that the gene set shared by all autotrophs whose genomes have been sequenced includes a large number of metabolic functions, indicating that these diverse organisms share a significant repertoire of biochemical pathways (Table 5).” |