15 - 20 %
||Rat Rattus norvegicus
||Anastacio MM et al., Relationship between mitochondrial matrix volume and cellular volume in response to stress and the role of ATP-sensitive potassium channel. Circulation. 2013 Sep 10 128(11 Suppl 1):S130-5. doi: 10.1161/CIRCULATIONAHA.112.000128 p.S131 left column 3rd paragraphPubMed ID24030396
|| Dos Santos P et al., Mechanisms by which opening the mitochondrial ATP- sensitive K(+) channel protects the ischemic heart. Am J Physiol Heart Circ Physiol. 2002 Jul283(1):H284-95 DOI: 10.1152/ajpheart.00034.2002PubMed ID12063301
||Primary source abstract: "Diazoxide opening of the mitochondrial ATP-sensitive K(+) (mitoK(ATP)) channel protects the heart against ischemia-reperfusion injury by unknown mechanisms. [Investigators] investigated the mechanisms by which mitoK(ATP) channel opening may act as an end effector of cardioprotection in the perfused rat heart model, in permeabilized fibers, and in rat heart mitochondria."
||P.S131 left column 3rd paragraph: "Open mKATP channels result in mitochondrial uptake of potassium and associated inorganic phosphates, anions, and water and cells achieve a 15% to 20% increase in steady state matrix volume in the mitochondria [primary source]."