Increase in steady state matrix volume in the mitochondria following opening of mKATP (mitochondrial ATP-sensitive potassium) channels

Range 15 - 20 %
Organism Rat Rattus norvegicus
Reference Anastacio MM et al., Relationship between mitochondrial matrix volume and cellular volume in response to stress and the role of ATP-sensitive potassium channel. Circulation. 2013 Sep 10 128(11 Suppl 1):S130-5. doi: 10.1161/CIRCULATIONAHA.112.000128 p.S131 left column 3rd paragraphPubMed ID24030396
Primary Source [10] Dos Santos P et al., Mechanisms by which opening the mitochondrial ATP- sensitive K(+) channel protects the ischemic heart. Am J Physiol Heart Circ Physiol. 2002 Jul283(1):H284-95 DOI: 10.1152/ajpheart.00034.2002PubMed ID12063301
Method Primary source abstract: "Diazoxide opening of the mitochondrial ATP-sensitive K(+) (mitoK(ATP)) channel protects the heart against ischemia-reperfusion injury by unknown mechanisms. [Investigators] investigated the mechanisms by which mitoK(ATP) channel opening may act as an end effector of cardioprotection in the perfused rat heart model, in permeabilized fibers, and in rat heart mitochondria."
Comments P.S131 left column 3rd paragraph: "Open mKATP channels result in mitochondrial uptake of potassium and associated inorganic phosphates, anions, and water and cells achieve a 15% to 20% increase in steady state matrix volume in the mitochondria [primary source]."
Entered by Uri M
ID 116933