Volume of PAM (Pulmonary Alveolar Macrophages)

Value 623 µm^3
Organism Rat Rattus norvegicus
Reference Haley PJ, Muggenburg BA, Weissman DN, Bice DE. Comparative morphology and morphometry of alveolar macrophages from six species. Am J Anat. 1991 Aug191(4):401-7 DOI: 10.1002/aja.1001910407 p.403 right column 2nd paragraphPubMed ID1951138
Primary Source Davies P, Sornberger GC, Engel EE, Huber GL. Stereology of lavaged populations of alveolar macrophages: effects of in vivo exposure to tobacco smoke. Exp Mol Pathol. 1978 Oct29(2):170-82PubMed ID689140
Method P.403 right column 2nd paragraph: "Davies et al. (1977) fixed rat PAM in glutaraldehyde-osmium, embedded them in Epon, and sectioned them at 1 µm. Using this technique, the volumes of PAM for control rats were 623 µm^3 in one study (primary source) and 871 µm^3 in another." Primary source abstract: "A multi-level morphometric and stereologic study was performed on alveolar macrophages obtained by bronchopulmonary lavage of unexposed control rats and rats experimentally exposed to whole tobacco cigarette smoke for 90 consecutive days. Measurements of macrophage profile diameters made at the light microscope were used to derive cell size distribution curves, with a mean cell volume in the control group of 623 μm^3."
Entered by Uri M
ID 116925