Number of genes with high homology that are conserved among all strains (the core genome)

Value 2000 genes
Organism Bacteria Escherichia coli
Reference Tenaillon O, Skurnik D, Picard B, Denamur E. The population genetics of commensal Escherichia coli. Nat Rev Microbiol. 2010 Mar8(3):207-17. doi: 10.1038/nrmicro2298 p.210 left column top paragraphPubMed ID20157339
Primary Source [55] Hendrickson H. Order and disorder during Escherichia coli divergence. PLoS Genet. 2009 Jan5(1):e1000335. doi: 10.1371/journal.pgen.1000335PubMed ID19165327
Comments P.209 right column bottom paragraph: "However, before many genomes were fully sequenced, the genomic era shifted the debate to another form of recombination: the acquisition and loss of genes, or horizontal gene transfer. Indeed, the most striking difference among strains at the genomic level is the variation in gene content [refs 53,54]. This is illustrated by an analysis of genomes of 20 different E. coli strains. This analysis found that the average E. coli genome contains 4,721 genes, but only 2,000 genes with high homology are conserved among all strains, these conserved genes form the core genome [primary source]." P.210 right column 3rd paragraph: "These five groups were recovered using the 1,878 genes of the Escherichia spp. core genome and the 2.6 million nucleotides of the E. coli chromosomal backbone [ref 57]."
Entered by Uri M
ID 116917