ATP flux through VDAC1 (voltage-dependent anion channel 1) in high ATP concentrations

Value 50000 ATP/sec
Organism Bread mold Neurospora crassa
Reference Choudhary OP, Paz A, Adelman JL, Colletier JP, Abramson J, Grabe M. Structure-guided simulations illuminate the mechanism of ATP transport through VDAC1. Nat Struct Mol Biol. 2014 Jul21(7):626-32. doi: 10.1038/nsmb.2841 p.629 right column top paragraphPubMed ID24908397
Primary Source [12] Rostovtseva T, Colombini M. VDAC channels mediate and gate the flow of ATP: implications for the regulation of mitochondrial function. Biophys J. 1997 May72(5):1954-62 DOI: 10.1016/S0006-3495(97)78841-6 [13] Rostovtseva T, Colombini M. ATP flux is controlled by a voltage-gated channel from the mitochondrial outer membrane. J Biol Chem. 1996 Nov 8 271(45):28006-8PubMed ID9129800, 8910409
Comments P.629 right column top paragraph: "The average rate based on these MFPTs [mean first passage times] is ~49,000 ATP/s, a result in excellent agreement with the experimental value of 50,000 ATP/s recorded from Neurospora crassa VDAC channels recorded in high ATP concentrations and extrapolated down to 5 mM ATP [primary sources]."
Entered by Uri M
ID 116877