Neutrophil speed during chemotaxis

Value 19 µm/min Range: ±6 µm/min
Organism Human Homo sapiens
Reference Hoang AN et al., Measuring neutrophil speed and directionality during chemotaxis, directly from a droplet of whole blood. Technology (Singap World Sci). 2013 Oct 2 1(1):49 DOI: 10.1142/S2339547813500040 abstractPubMed ID24809064
Method Abstract: "To address the need for rapid and robust assays, [investigators] designed a microfluidic device that measures neutrophil chemotaxis directly from a single droplet of blood. [They] validated the assay by comparing neutrophil chemotaxis from finger prick, venous blood and purified neutrophil samples. [They] found consistent average velocity of (19 ± 6 μm/min) and directionality (91.1%) between the three sources."
Comments P.5 bottom paragraph: "Neutrophil velocity from finger prick whole blood was comparable for both fMLP (N-Formylmethionyl-leucyl-phenylalanine, 19 ± 6 μm/min) and LTB4 (Leukotriene B4, 20 ± 7 μm/min) (Fig. 4b)."
Entered by Uri M
ID 116690