Fraction of proteins that are cleared by the proteasome

Range 70% - 90 %
Organism Eukaryotes
Reference Theillet FX et al., Physicochemical properties of cells and their effects on intrinsically disordered proteins (IDPs). Chem Rev. 2014 Jul 9 114(13):6661-714. doi: 10.1021/cr400695p p.6674 left column top paragraphPubMed ID24901537
Primary Source [282] Lee DH, Goldberg AL. Proteasome inhibitors: valuable new tools for cell biologists. Trends Cell Biol. 1998 Oct8(10):397-403 [283] Rock KL, Inhibitors of the proteasome block the degradation of most cell proteins and the generation of peptides presented on MHC class I molecules. Cell. 1994 Sep 9 78(5):761-71PubMed ID9789328, 8087844
Method Primary source [283] abstract: "[Investigators] used these agents [Peptide aldehydes that inhibit major peptidase activities of the 20S and 26S proteasomes] to test the importance of the proteasome in antigen presentation."
Comments P.6674 left column top paragraph: "70–90% of all eukaryotic proteins are cleared by the proteasome (primary sources) and 40% of all cellular proteasomes exist as 20S proteasomal core units, with poorly defined activities (BNID 116242)."
Entered by Uri M
ID 116240