| Range |
fully disordered protein domains 57%: partially disordered domains 24%: ordered regions 19 %
|
| Organism |
Human Homo sapiens |
| Reference |
Theillet FX et al., Physicochemical properties of cells and their effects on intrinsically disordered proteins (IDPs). Chem Rev. 2014 Jul 9 114(13):6661-714. doi: 10.1021/cr400695p p.6673 left column 2nd paragraphPubMed ID24901537
|
| Primary Source |
[261] Romero PR et al., Alternative splicing in concert with protein intrinsic disorder enables increased functional diversity in multicellular organisms. Proc Natl Acad Sci U S A. 2006 May 30 103(22):8390-5 DOI: 10.1073/pnas.0507916103PubMed ID16717195
|
| Method |
Primary source abstract: "[Investigators] analyzed a set of 46 differentially spliced genes encoding experimentally characterized human proteins containing both structured and intrinsically disordered amino acid segments." |
| Comments |
P.6673 left column 2nd paragraph: "Dunker and co-workers analyzed 46 alternatively spliced human genes and found that 81% of all alternative splice sites occur in fully (57%) or partially (24%) disordered protein domains. Only 19% occur in ordered regions (primary source)." Primary source abstract: "[Investigators] show that 81% of 75 alternatively spliced fragments in these proteins were associated with fully (57%) or partially (24%) disordered protein regions." |
| Entered by |
Uri M |
| ID |
116235 |