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Average hydrodynamic radii of fibrillar tau

Range	~90 nm
Organism	Bacteria Escherichia coli
Reference	Theillet FX et al., Physicochemical properties of cells and their effects on intrinsically disordered proteins (IDPs). Chem Rev. 2014 Jul 9 114(13):6661-714. doi: 10.1021/cr400695p p.6669 left column 2nd paragraphPubMed ID24901537
Comments	P.6669 left column 2nd paragraph: "However, when one considers the average hydrodynamic radii of IDP [intrinsically disordered protein] aggregates (∼90 nm for fibrillar tau, for instance), oligomeric IDP species may exhibit reduced intracellular diffusion (see section 2.3.2). In fact, IDP aggregates may constitute barriers to intracellular translational diffusion and increase intracellular viscosity or exacerbate the effects of existing sieve-like structures."
Entered by	Uri M
ID	116216